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December 1985, Volume 35, Issue 12


Editorial

MECHANISMS OF RESISTANCE TO METHOTREXATE

M. Perwaiz Iqbal

Methotrexate (MTX) is a folate antagonist which kills the proliferating cell by binding tightly to the enzyme dihydrofolate reductase (DHFR). Due to this binding the pathway of de novo DNA synthesis is blocked1-3. The drug has produced spectacular results co

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